Lin Hou Associate Professor

Research Areas: statistical genetics, bioinformatics, applied statistics

Office: Room 210, Weiqing Building, Tsinghua University

Phone: +86-10-62789162


  • Ph.D, Peking University
  • Postdoc Associate, Yale University (2012)
  • Associate Research Scientist, Yale University (2012-2014)

  • Statistical genetics
  • Bioinformatics
  • Applied statistics

  • Guo H, Li J, Lu Q#, and Hou L#. (2021) Detecting local genetic correlations with scan statistics. Nature Communications, 12(1):2033.
  • Li R, Chen B, Zhang T, Ren Z, Song Y, Xiao Y, Hou L, Cai J, Xu B, Li M, Chan K, Tu Y, Yang M, Yang J, Liu Z, Shen C, Wang C, Xu L, Liu Q, Bao S, Zhang J, Bi Y, Bai Y, Deng K, Zhang W,
  • Huang W, Whittington J, Stenseth N, Guan D, Gong P, and Xu B. (2020) Global COVID-19 pandemic demands joint interventions for the suppression of future waves. Proceedings of the National Academy of Sciences, 117(42):26151-26157.
  • Yu B, Lu Y, Zhang QC, and Hou L#. (2020) Prediction and differential analysis of RNA secondary structure. Quant Biol,
  • Song S, Jiang W, Hou L, and Zhao H. (2020) Leveraging effect size distributions to improve polygenic risk scores derived from summary statistics of genome-wide association studies. PLOS Computational Biology, 16(2): e1007565
  • Li G, Hou L, Liu X, and Wu C. (2020) A weighted empirical Bayes risk prediction model using multiple traits. Statistical Applications in Genetics and Molecular Biology, 19(3):20190056
  • Shan N, Li N, Dai Q, Hou L, Yan X, Amei A, Lu L, and Wang Z. (2020) Interplay of tRNA-derived fragments and T cell activation in breast cancer patient survival. Cancers, 12(8):2230
  • Si Y, Wei J, Wu W, Zhang W, Hou L, Yu L, and Wielstra B. (2020) Reducing human pressure on farmland could rescue China's declining wintering geese. Movement Ecology, 8(1):35
  • Jiang W, Song S, Hou L, and Zhao H. (2020) A set of efficient methods to generate high-dimensional binary data with specified correlation structures. American Statistician, DOI: 10.1080/00031305.2020.1816213
  • Shan N, Wang Z#, and Hou L#. (2019) Identification of trans-eQTLs using mediation analysis with multiple mediators. BMC Bioinformatics, Suppl 3:126
  • Hou L, Sun N, Mane S, Sayward F, et al. (2017) Impact of genotyping errors on statistical power of association tests in genomic analyses: A case study. Genetic Epidemiology, 41:152-162
  • Williams K, Colangelo C, Hou L, Chung L, et al. (2017) Use of a targeted urine proteome array (TUPA) to identify protein biomarkers of delayed recovery after kidney transplant. Proteomics Clin Appl, 11:1600132
  • Evans B, Gloria-Soria A, Hou L, McBride C, Bonizzoni M, Zhao H and Powell J. (2015) A multipurpose high throughput SNP chip for the Dengue and Yellow Fever mosquito, Aedes aegypti. G3 (Bethesda), 5:711-718.
  • Xie Y, Jin Y, Merenick B, Ding M, Fetalvero K, Wagner R, Mai A, Gleim S, Tucker D, Birnbaum M, Ballif B, Luciano A, Sessa W, Rzucidlo E, Powell R, Hou L, Zhao H, Hwa J, Yu J, Martin K. (2015) Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition. Science Signaling, 8(376):ra44.
  • Foxman E, Storer J, Fitzgerald M, Wasik B, Hou L, Zhao H, Turner P, Pyle A and Iwasaki A. (2015) Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells. Proceedings of the National Academy of Sciences, 112(3):827-32.
  • Tadeu A, Lin S, Hou L, Chung L, Zhong M, Zhao H and Horsley V. (2015) Transcriptional profiling of ectoderm specification to keratinocyte fate in human embryonic stem cells. PLoS One, 10:e0122493.
  • Hou L, Chen M, Zhang K, Cho J and Zhao H. (2014) Guilt by rewiring: gene prioritization through network rewiring in Genome Wide Association Studies. Human Molecular Genetics, 23:2780-2790.
  • Hou L*, Ma T* and Zhao H. (2014) Incorporating functional annotation information in prioritizing disease associated SNPs from genome wide association studies. SCIENCE CHINA Life Sciences, 57:1072-1079.
  • Brownstein C, et al. (including Hou L) (2014) An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biology, 15:R53.
  • Gao Y, Nish S, Jiang R, Hou L, Licona-Limon P,Weinstein J, Zhao H and Medzhitov R. (2013) Control of T Helper 2 Responses by Transcription Factor IRF4-Dependent Dendritic Cells. Immunity, 39:1-11.
  • Hou L and Zhao H. (2013) A review of post-GWAS prioritization approaches. Frontiers in Genetics, 4:280.
  • Hou L, Wang L, Berg A, Qian M, Zhu Y, Li F and Deng M. (2012) Comparison and evaluation of network clustering algorithms applied to genetic interaction networks. Frontiers in Bioscience, 4:2150-2161.
  • Wang L, Hou L, Qian M and Deng M. (2012) Integrating phosphorylation network with transcriptional network reveals novel functional relationships. PLoS one, 7:e33160. (co-first author)
  • Hou L, Wang L, Qian M, Li D, Tang C, Zhu Y, Deng M and Li F. (2011) Modular analysis of the probabilistic genetic interaction network. Bioinformatics, 27:853-859.
  • Wang L, Hou L, Qian M, Li F and Deng M. (2011) Integrating multiple types of data to predict novel cell cycle-related genes. BMC Systems Biology, 5(Suppl 1):S9.
  • Liu Z, Liu Q, Sun H, Hou L, Guo H, Zhu Y, Li D and He F. (2011) Evidence for the additions of clustered interacting nodes during the evolution of protein interaction networks from network motifs. BMC Evolutionary Biology, 11:133.
  • Wu X, Wu S, Li D, Zhang J, Hou L, Ma J, Liu W, Ren D, Zhu Y and He F. (2010) Computational identification of rare codons of Escherichia coli based on codon pairs preference. BMC Bioinformatics, 11:61.
  • Cai X*, Hou L*, Su N*, Hu H, Deng M and Li X. (2010) Systematic identication of conserved motif modules in the human genome. BMC Genomics, 11:567. (co-first author)
  • Hou L, Qian M, Zhu Y and Deng, M. (2009) Advances on bioinformatic research in transcription factor binding sites. Hereditas, 31:365-373.